Ok I did some testing on it using it left handed, I am not left handed so results may very. I was able to open a can with the P38.5 lefty but it was difficult (hurt my hand to hold the tool), not sure if it's because i am not left handed or it's the design (angle of the bevel towards the cutting side. I don't see why it cannot open a can with either hand whether you are left or right handed.