I think the only Leatherman I found uncomfortable to use is the pliers/scissors on the Style PS/CS. I have a Style CS that I was using to trim my nails, but the only way to get a good grip also jabs the handle into my palm. I tried the pliers on the Style PS on a small nut, and it's the same.
The same Leatherman might not be the most comfortable under both criteria; indeed, I consider the PST to be the most comfortable with handles closed, but the least comfortable with handles open.