Yeah, it was weird... I was goofing off with my Outrider today when it hit me... I've always wondered whey the blade is on the right side of the knife... I've always thought it should be on the left side if you're right handed (like I am), because then the blade would be closer to the work...
That's when it hit me. The blade sticks up more than any other tool in the knife (except for the pliers, like on the Work Champ), so if the blade was on the other side, it would block access to all the other tools with the left hand.
I think it makes sense for the lock to be on that side too; if you're right handed, and using the knife, if it was the other way around that would put the button for the lock right under your thumb, and increase the chance of accidentally opening the lock during use.
So call me Sherlock for a while!